By Silvio Garattini and Parkhurst A. Shore (Eds.)
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Their action may resemble the first phase of phlogistic process, but neither kinins nor histaniine can be made responsible for the second, delayed increase in pernieability (Miles, 1964). , 196l), but kinins are relatively ineffective in promoting migration of leucocytes (Spector and Willoughby, 1964). They induce this phenomenon only in relatively high concentration (1-100 pg/ml) (Lewis, 1961, 1962). The claim that topical application of bradykinin causes the sticking of leucocytes in the venules of the mesentery (Lewis, 1962) has not been confirmed (Zweifach, 1964).
Another source of discrepancy niighh have been the difference in temperature during the handling of plasma. , 1965). A decrease in the kininogen level in blood during delivery was also observed by Periti et al. (1962). , 1963). , 1963a). , 1950), in colostrum (Werle, 1960; Guth, 1959), in bone marrow (Werle and Preisser, 1956), and in lymph (Schachter, 1960), but not in the cellular elements of blood. Bradykininogen niay originate from the liver, since CCI, treatment orhepatectomy decreases its level in rabbits (Diniz and Carvalho, 1963).
1964b). , 1961; Mitchell and Krell, 1964). Kallikrein causes severe itching when administered intradermally (Cormia and Dougherty, 1960). Kallidin is a somewhat less active pain-producing agent than bradykinin in man. , 1965). No evidence for tachyphylaxis was seen in these latter experiments. Bradykinin also causes conditions which are considered to be painful to various animals. , 1964) measured the vocalization which follows the intraarterial HYPOTENSIVE PEPTIDES 35 injection of bradykinin.