By James L Bittle; Frederick A Murphy
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Additional resources for Advances in veterinary science and comparative medicine. Vol. 33, Vaccine biotechnology
S. pneumoniae tetani A. Corynebacterium The genus Corynebacterium is a heterogeneous grouping with its species placed together largely on the basis of similar cell wall components (Goodfellow and Minnikin, 1981). These species share a basic cell wall chemistry (Barksdale, 1981) of which the mycolic acids (Silva and Ioneda, 1977), especially trehalose dimycolate, are frequently used as potent adjuvants in immunization protocols. Two corynebacteria—C. pyogenes and C. pseudotuberculosis—are important in veterinary medicine.
The problem in developing a vaccine for feline leukemia was to find immunogens that could be used without exposing animals to oncogenic materials. , 1976). , 1979), their oncogenic potential makes them unacceptable. Efforts to develop vaccines containing only viral proteins, such as envelope protein, have had variable results. However, cultivation of FeLV in FL 74transformed cells, followed by treatment to release viral and cell proteins, yields a vaccine t h a t stimulates antibodies to both viral and cell membrane components.