By Mary J. Laughlin, Hillard M. Lazarus
Across the world well-known physicians and researchers evaluate either the fundamentals of allogeneic stem phone transplantation and up to date advances within the box, relatively as they relate to antitumor results and graft-versus-host illness in addition they supply precise decision-tree analyses to lead clinicians in picking out and coping with their allogeneic transplant sufferers. The strategies mentioned disguise various parts, starting from stem mobile mobilization in general donors, to symptoms for allogeneic transplantation except hematologic malignancies, to using nonmyeloablative conditioning regimens. The authors additionally discover new advancements within the optimum number of unrelated allogeneic grafts (e.g., matched unrelated donor, in part mismatched loved one, or umbilical wire blood), the use allogeneic peripheral blood stem mobile vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.
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Extra resources for Allogeneic Stem Cell Transplantation (1st Edition)
DFS and OS were dependent on pretransplant bone marrow blast counts. Patients with RA/RARS, RAEB, RAEB-T, and sAML had a 5-yr DFS Chapter 2 / Allogeneic BMT for AML 21 of 52, 34, 19, and 26%, respectively, while the 5-yr OS for the respective patient groups was 57, 42, 24, and 28%, respectively. In a multivariate analysis, younger age, shorter disease duration, and absence of excess of blasts were associated with improved outcome. 13. IPSS SCORE AND RESULTS OF BMT FOR MDS Several classification systems have been used for evaluating prognosis in patients with MDS, including the French–American–British (FAB) system.
Clinical significance of cytogenetics in acute myeloid leukemia. Semin Oncol 1997;24:17–31. 13. Fenaux P, Chastang C, Chevret S, et al. A randomized comparison of all-transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and the role of maintenance therapy in newly diagnosed acute promyelocytic leukemia. Blood 1999;94:1192–1200. 14. Niu C, Yam H, Yu T, et al. Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients.
Thus, both the large IBMTR retrospective review and the LALA study suggest a clear role for allogeneic SCT over consolidation chemotherapy in younger adults with high-risk features in CR1. Another study by Oh et al. reinforces the observation that a significant survival advantage is gained in high-risk younger patients undergoing allogeneic SCT (20). Presumably, the lower mortality and morbidity sustained by younger patients undergoing SCT highlights the advantage of this method over chemotherapy.