Download An introduction to immunotoxicology by Jacques Descotes PDF

By Jacques Descotes

This article offers a concise and entire creation to key immunotoxicological matters for all these attracted to, yet without previous wisdom of, this zone of toxicology. the 1st part explores the overall healthiness effects of immunotoxicity, particularly the antagonistic results with regards to chemically-induced immunosuppression and immunostimulation, allergic reaction reactions and autoimmune illnesses, with an summary of significant immunotoxicants. the second one half describes the newest equipment used to notice and overview, preclinically and clinically, the unforeseen immunotoxic results of xenobiotics. tendencies in imposing suggestions and up to date alterations to the regulatory features also are thought of. The 3rd part examines attainable destiny advancements, together with In Vitro equipment, biomarkers of immunotixicity and chance review.

Show description

Read Online or Download An introduction to immunotoxicology PDF

Best toxicology books

Uncertainty Modeling in Dose Response: Bench Testing Environmental Toxicity

A important advisor to figuring out the matter of quantifying uncertainty in dose reaction family for poisonous substancesIn cutting-edge clinical learn, there exists the necessity to deal with the subject of uncertainty because it relates to dose reaction modeling. Uncertainty Modeling in Dose reaction is the 1st booklet of its style to enforce and examine varied equipment for quantifying the uncertainty within the likelihood of reaction, as a functionality of dose.

Compendium of Trace Metals and Marine Biota: Volume 2: Vertebrates

Every one booklet has major goals1. ensure baseline concentrations of metals and metalloids in tissues of consultant box populations of estuarine coastal, and open ocean organisms (Book 1:algae and macrophytes, protists, sponges, coelenterates, molluscs, crustaceans, bugs, chaetognaths, annelids, echinoderms, and tunicates) (Book 2: elasmobranchs, fishes, reptiles, birds, mammals) and their value to organism future health and to the health and wellbeing in their shoppers.

Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification (Methods in Pharmacology and Toxicology)

Dr. Myrtle A. Davis has assembled a panel of state-of-the-art scientists to explain their most sensible tools for detecting, illuminating, and quantifying apoptotic mechanisms in a manner that's priceless for the layout of toxicology and pharmacology stories. those cutting-edge recommendations comprise circulation cytometric, fluorometric, and laser scanning tools for quantifying and characterizing apoptosis, in addition to protocols for using DNA microarray expertise, excessive throughput displays, and ELISA.

Biomarkers in Toxicology

Biomarkers in Toxicology is a well timed and finished reference devoted to all elements of biomarkers that relate to chemical publicity and their results on organic structures. This e-book comprises either vertebrate and non-vertebrate species versions for toxicological trying out and improvement of biomarkers.

Additional resources for An introduction to immunotoxicology

Sample text

Clin. Immunol. , 26, 10–17. D. (1990) Drug interactions involving immunologic agents. Part I. Vaccinevaccine, vaccine-immunoglobulin, and vaccine drug interactions. DICP, Ann. , 24, 67–81. W. R. (1983) Depression of theophylline elimination following BCG vaccination. Br. J. Clin. , 16, 735–737. , et al. (1989) Effects of interferon-a on theophylline pharmacokinetics and metabolism. Br. J. Clin. , 27, 795–802. KOREN, G. and GREENWALD, M. (1985) Decrease in theophylline clearance causing toxicity during viral epidemics.

Several cytokines have neurotransmitter activity and their possible role in psychiatric diseases is an area of growing research. , 1994). The impact of the immune system on other physiological functions is still poorly recognised, although it may account for adverse effects caused by immunomodulating compounds. Conclusion This brief overview of the immune system shows how complex and intricated immune responses can be, due to the interplay of many redundant or conflicting mechanisms. In addition, other biological systems, such as the second messengers or the complement pathway, are involved.

S. R. (1991) AIDS, drugs of abuse and the immune system: a complex immunotoxicological network. Arch. , 65, 609–617. P. (1990) Iatrogenic immunodeficiencies. Curr. Op. , 2, 445–450. D. P. (1995) The primary immunodeficiencies. N. Engl. J. , 333, 431–440. H. (1993) Impact of cytomegalovirus infection on organ transplant recipients. Rev. Infect. , 12, S754–S766. H. S. (1994) Clinical Approach to Infection in the Compromised Host, 3rd edition. New York: Plenum Medical. H. C. (1997) Infectious complications of immunosuppressive therapy in patients with rheumatic diseases.

Download PDF sample

Rated 4.57 of 5 – based on 48 votes