Download Carbon monoxide and cardiovascular functions by Rui Wang PDF

By Rui Wang

Equivalent to nitric oxide, carbon monoxide (CO) was once at the beginning seen as a natural poisonous fuel, but it's been lately tested to be a massive endogenous molecule of gasoline that has profound physiological and pathophysiological results at the cardiovascular procedure. even with the starting to be realizing accomplished during this box, in the past a finished booklet summarizing the intense advances within the examine of the cardiovascular results of CO has no longer been to be had. Carbon Monoxide and Cardiovascular features responds to the vexing demanding situations and intriguing possibilities that confront researchers and clinicians learning the organic roles of CO within the cardiovascular process. This ebook offers many never-before-published effects together with the 1st case of human CO deficiency. It additionally discusses issues the place the cardiovascular results of CO could have been altered, together with high blood pressure, diabetes, stroke, and ischemic middle damage.A fabricated from the amassed wisdom of across the world revered scientists, this publication serves as a regular reference summarizing contemporary advancements, medical controversies, and destiny instructions within the learn of the organic activities of CO at the cardiovascular method. through overlaying either historical and cutting-edge methodologies in nice element, Carbon Monoxide and Cardiovascular services, provides a swift mastery of the strong new advances in CO learn.

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37 4. 37 5. 38 V. 39 I. OVERVIEW OF THE VASCULAR EFFECTS OF CO The vascular production of carbon monoxide (CO) and the vascular effects of this gas have been known for more than half a century. Soon after the discovery in the late 1940s of the endogenous production of CO in humans during heme catabolism,1 the vascular effect of CO was detected by Duke and Killick2 who showed that CO decreased pulmonary vascular resistance. In the following 40 years, the reputation of CO as a toxic hypoxic gas was widely known.

50 © 2002 by CRC Press LLC © 2002 by CRC Press LLC 23 1041Ch02Frame Page 24 Tuesday, August 28, 2001 10:12 AM 24 Carbon Monoxide and Cardiovascular Functions 3. 37 4. 37 5. 38 V. 39 I. OVERVIEW OF THE VASCULAR EFFECTS OF CO The vascular production of carbon monoxide (CO) and the vascular effects of this gas have been known for more than half a century. Soon after the discovery in the late 1940s of the endogenous production of CO in humans during heme catabolism,1 the vascular effect of CO was detected by Duke and Killick2 who showed that CO decreased pulmonary vascular resistance.

Heme oxygenase 1 is required for mammalian iron reutilization. Proc. Natl. Acad. Sci. , 94, 10919, 1997. 86. D. , Reduced stress defense in heme oxygenase 1-deficient cells, Proc. Natl. Acad. Sci. , 94, 10925, 1997. 87. Yachie, A. , What did we learn from the first case of human heme oxygenase1 deficiency? , 103 (Suppl. 1), 82, 2000. 88. , Carbon monoxide-induced relaxation of the ductus arteriosus in the lamb: evidence against the prime role of guanylyl cyclase, Br. J. , 118, 1689, 1996. 89.

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