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By D. M. Jerina, J. M. Sayer, D. R. Thakker (auth.), Bernard Pullman, Paul O. P. Ts’o, Harry Gelboin (eds.)

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Read Online or Download Carcinogenesis: Fundamental Mechanisms and Environmental Effects: Proceedings of the Thirteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, April 28 – May 2, 1980 PDF

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Extra info for Carcinogenesis: Fundamental Mechanisms and Environmental Effects: Proceedings of the Thirteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, April 28 – May 2, 1980

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Biol. Interact. 20, pp. 1726. 5. , Grover, P. : 1978, Biochem. Biophys. Res. Commun. 85, pp. 1568-1574. 6. Thakker, D. , Wood, A. , Conney, A. , Stoming, T. , and Jerina, D. : 1978, J. ArneI'. Chern. Soc. 100, pp. 645-647. 7. , Osborne, M. : pp. 564-571. 8. Weinstein, 1. , Jeffrey, A. : 1978, "Polycyclic Hydrocarbons and Cancer", Gelboin, H. V. , Academic Press, New York, N. , Vol. 2, Chap. 1, pp. 3-36. 9. Jerina, D. , and Lehr, R. : 1977, "Microsomes and Drug Oxidations", Ullrich, V. , Pergamon, Oxford, pp.

04 r-O ""'0 Carcinogenicity** < 10 0 0 Th~ ratio of ESR signal of the sample to that of standard sample of Mn + is normalized by the protein concentration. Each value is the average of five experiments. l,pp339-396. 2. Free Radical Formation in vivo After oral administration of 3 '-Me-DAB to rats, the livers were removed and extracted with benzene. The ESR signal (Fig. 8) of the extract was the same as that observed in the in vitro experiment (Fig. 4). The clear signal was detected at 6 hr after oral administration.

Proc. Natl. Acad. Sci. USA, 1977 (12,13); Fig. 8, Harvey, "Safe Handling of Chemical Carcinogens, Mutagens, Teratogens, and Highly Toxic Substances", Ann Arbor Science Publishers, 1980 (25); and Fig. , Biochem. Biophys. Res. , 1979 (23). )-9, 10-epoxy-7 ,8,9, 10-tetrahydro-BP; BA, benz [a] anthracene; DB A, dibenz [a,h] anthracene; BeP, benzo [e] pyrene. C. HARVEY ET AL. REFERENCES 1. "Polycyclic Bydrocarbons and Cancer", Gelboin, H. V. , 1978. 2. Slaga, T. , Gleason, G. , Sukumaran, K. , and Harvey, R.

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