Download Casarett & Doull's Toxicology: The Basic Science of Poisons by Curtis D. Klaassen PDF

By Curtis D. Klaassen

The such a lot entire, depended on reference textual content masking the total span of scientific toxicology

A Doody's center identify crucial buy for 2011!

"This reference stands by myself because the simple textual content within the box of toxicology. This authoritative reference is written via many individual execs within the box, and provides transparent, concise descriptions of the main strategies in toxicology. it's vast and whole, masking a extensive diversity of themes in adequate aspect. either as a reference and as an instructional device, this booklet exceeds its aim of serving as a reference for toxicologists, different scientists, and scholars of the self-discipline. three Stars."--Doody's assessment Service

Long validated because the premiere within the box, Casarett & Doull's Toxicology equips you with an unsurpassed knowing of recent toxicology, together with the rules, recommendations, mechanisms, and modes of suggestion which are the basis of the self-discipline. the recent 7th version gains is up to date all through and contains many new participants and new content material on chemical terrorism.

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Sample text

However, some of these side effects may be desired for another therapeutic indication. For example, the “first-generation” antihistamine diphenhydramine (Benadryl) is effective in reducing histamine responses associated with allergies, but it readily enters the brain and causes mild central nervous system (CNS) depression (drowsiness, delayed reaction time). With the advent of newer and selective histamine receptor antagonists that do not cross the blood–brain barrier and thus do not have this CNSdepressant side effect, diphenhydramine is used less commonly today as an antihistamine.

For example, an agent that acts on the CNS, but is efficiently detoxified in the liver, would be expected to be less toxic when given orally than when given via inhalation, because the oral route requires that nearly all of the dose pass through the liver before reaching the systemic circulation and then the CNS. Occupational exposure to toxic agents most frequently results from breathing contaminated air (inhalation) and/or direct and prolonged contact of the skin with the substance (dermal exposure), whereas accidental and suicidal poisoning occurs most frequently by oral ingestion.

The unusual phenotype is inherited as an autosomal recessive trait and is characterized by a deficiency in NADH-cytochrome b5 reductase activity. , 1990). The consequence of this genetic deficiency is that these individuals may suffer from a Some toxic effects of chemicals are reversible, and others are irreversible. If a chemical produces pathological injury to a tissue, the ability of that tissue to regenerate largely determines whether the effect is reversible or irreversible. Thus, for a tissue such as liver, which has a high ability to regenerate, most injuries are reversible, whereas injury to the CNS is largely irreversible because differentiated cells of the CNS cannot divide and be replaced.

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