Download Casarett & Doull's Toxicology The Basic Science of Poisons, by Curtis Klaassen PDF

By Curtis Klaassen

The main depended on all-in-one evaluate of the biomedical and environmental elements of toxicology--NOW extra whole, up to date, and in complete color
The worlds best and such a lot authoritative textbook on poisons has extra to provide students,toxicologists, and pharmacologists than ever sooner than. Now in complete colour, and punctiliously revised, the 8th version of Casarett & Doulls TOXICOLOGY: the fundamental technological know-how of toxins not just supplies a finished evaluation of the basic elements of toxicology, it bargains the main up to date, revealing, and in-depth examine the systemic responses of poisonous substance to be had anywhere.
Combined with the newest pondering via the fields ultimate students plus reliable insurance of basic ideas, modes of motion, and chemical-specific toxicity, this landmark textual content maintains to set the normal for toxicology references.
NEW to the 8th Edition
- FULL-COLOR layout to permit for a clearer interpretation of the fundamental elements of toxicology featured during the text
- extended tables, illustrations, and different visuals are up-to-date with state of the art criteria that makes this version much more present and relevant
- NEW CHAPTERS comprise «Toxic results of energy» and «Toxic results of Nanoparticles»

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Extra info for Casarett & Doull's Toxicology The Basic Science of Poisons, Eighth Edition

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Line B) A chemical with a rate of elimination equal to frequency of dosing (eg, 1 day). (Line C) Rate of elimination faster than the dosing frequency (eg, 5 hours). Blue shaded area is representative of the concentration of chemical at the target site necessary to elicit a toxic response. For many chemicals, the toxic effects that follow a single exposure are quite different from those produced by repeated exposure. For example, the primary acute toxic manifestation of benzene is CNS depression, but repeated exposures can result in bone marrow toxicity and an increased risk for leukemia.

It is generally thought that most, but not all, idiosyncratic drug responses are due to a combination of individual differences in the ability to: (1) form a reactive intermediate (usually through oxidation to an electrophilic intermediate), (2) detoxify Immediate toxic effects can be defined as those that occur or develop rapidly after a single administration of a substance, whereas delayed toxic effects are those that occur after the lapse of some time. Carcinogenic effects of chemicals usually have a long latency period, often 20 to 30 years after the initial exposure, before tumors are observed in humans.

But mechanistic studies over the past several decades have demonstrated that this drug may have a unique molecular mechanism of action that interferes with the expression of certain genes responsible for blood vessel formation (angiogenesis). With an understanding of this mechanism, thalidomide has been “rediscovered” as a valuable therapeutic agent that may be highly effective in the treatment of certain infectious diseases (eg, leprosy) and multiple myeloma. This provides an interesting example of how a highly toxic drug with selectivity toward a specific population (pregnant women) can be used relatively safely with proper precautions.

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