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By Moni Abraham Kuriakose

This is the second one of 4 volumes that jointly provide an authoritative, in-depth reference advisor protecting all elements of the administration of oral melanoma from a multidisciplinary point of view and at the foundation of a powerful clinical starting place. This quantity addresses a variety of administration concerns in oral melanoma, from imaging and staging via to the jobs of radiation remedy and chemotherapy. ideas of ablative surgical procedure are defined, and neck dissection and sentinel lymph node biopsy thoughts, defined. special attention is additionally given to the administration of issues, salvage surgical procedure and re-radiation, the biologic foundation of remedy failure, and rising techniques to beat therapy resistance. The inclusion of resource-stratified instructions will meet the wishes of practitioners in numerous geographic areas with various resources.

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The sublingual space, which contains the anterior parts of the hyoglossus m ­ uscle; the lingual nerve, artery, and vein; the glossopharyngeal and hypoglossal cranial 26 V. V. Sunil nerves; the sublingual glands and ducts; the deep component of the submandibular gland; and the submandibular (Wharton’s) duct [1, 4], is not encapsulated by fascia and is often involved in lesions of the floor of the mouth. Posteriorly, the masticator space and the infratemporal fossa are areas of special attention in the evaluation of disease spread.

1 Clinical Evaluation and Staging of Oral Cancer 21 32. Athanassiou-Papaefthymiou M, Shkeir O, Kim D, et al. Evaluation of CD44 variant expression in oral, head and neck squamous cell carcinomas using a triple approach and its clinical significance. Int J Immunopathol Pharmacol. 2014;27(3):337–49. 33. Nanda DP, Dutta K, Ganguly KK, et al. MMP-9 as a potential biomarker for carcinoma of the oral cavity: a study in eastern India. Neoplasma. 2014;61(6):747–57. 34. Kim JW, Roh JL, Park Y, et al. Cytoplasmic iASPP expression as a novel prognostic indicator in oral cavity squamous cell carcinoma.

The regional nerves of each space may be involved, showing the caudal and cranial extension of the tumor through perineural spread. The tumor size, extent and the precise estimation of the extent of intended surgical excision can be predicted by image analysis. As a general principle, if more than 30 % of the tissue needs to be removed, a reconstructive procedure is needed [7]. Mandibular invasion requires special reference, as the regional involvement directly translates to mandibular resection of varying degrees.

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