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5 chemistry, 3436 economics, 34119 growth phases, 345'7, 79 immobilized whole cells, 3499, 100 liquid surface fermentation, 34:58 mode of action, 3443 process, 34:85-87 regulation, 34:79-81 solid-state fermentation, 34:lOO submerged fermentation, 3464-67, 71 haloperoxidases, 37:56, 72, 77, 91 herbicides and pesticides and, 362, 6 anaerobic aromatic metabolism, 36:33 chloroaromatic metabolism, 36:23, 25-26 cometabolism, 3629 dicamba degradation, 36:48 growth kinetics, 36:49, 52-53, 60-61 kinetics of biodegradation, 36:12, 19-20 levan and, 35:181, 182 microbial cytochromes P450 and, 36:138,141-142,148, 166 monosaccharides and applications, 34:165, 167, 1 7 2 fermentation, 34:157 mechanisms, 34:144 structure, 34:150, 152-154 nitroaromatic compounds, 37:1, 7-9, 11, 14 in pristine aquifer, 33:152 recombinant E.

82 foodborne yeasts and, 36231-232 genetically engineered microorganisms and, 38:36 herbicides and pesticides and, 3636, 42 CUMULATIVE SUBJECT INDEX pBR322, 36:92, 97, 99 phenotypes with, genetically engineered microorganisms and, 38:32-35 recombinant E. coli K-12 and, 36105, 109,115,116-117,120,121 selection, 36:97-98 water, 36:102-103 Antibiotics 33-25, 24201-202 AB-1, 24:203 A-3302-B, 24~212 a-amylase production and, 35:lO anoxygenic phototrophic bacteria and, 38280 antibody technologies and, 38195 autotoxic, tolerance to, in producer organisms, 25:152-162 bacterial gene transfer in soil and, 35:62, 64 conjugation, 35:75, 77, 79, 80, 83 study methods, 35:122-125, 128 environmental factors, 35:67, 70 recombinants, 35:140-142 transduction, 35:102, 137, 138 biotechnology and, 34264, 280, 281 BU 1880,24:203 chorismate-derived production of, 25:75-93 common subunits of, 27:59 culture resistance to, 25:76-81 development of, 33:327 EM-49,24199-202 enzyme inactivation of, 25:78-80 extraction procedure, 33:326-330 feedback control of, 25:162-164 Ganoderrna, 37:102, 123 genetically engineered microorganisms and, 38:69, 91 gibberellins and, 3488, 101 product development, 40:166-169 secondary metabolism and, 34:5, 7-9, 12 similar subunit structures in, 28:33 substances from bacteria, 41:202-203 from fungi and ascomycetes, 34242, 243 basidiomycetes, 34238, 240, 241 fungi imperfecti, 34230-232, 234, 236 11 history, 34:184 phycomycetes, 34244 production, 34186-206 screening, 34:185 target-site modification by, 25:152-157 TL-119, 2 4 2 11-2 1 2 TM-743, 24~203 tolerance to by excretion-exclusion, 25:157-162 in producer organisms, 25:147-168 V-8495, 24~203 xenobiotics and, 35917 xenotoxic, 25:149-152 Antibodies anoxygenic phototrophic bacteria and, 38251 biotechnology and, 34:290, 292, 294 cellular cytotoxicity dependence on, antibody technologies and, 38:171, 175, 181 Ganoderrna, 37:118-119 hydrodynamic shear stress, 37201 labeling, hydrodynamic shear stress, 37:189 levan and, 35:180, 190 microbial cytochromes P450 and, 36:146, 151, 163 protein analysis and, 36291, 294, 316, 318, 323 Antibody technologies affinity chromatography, 38:160-161 enzyme immunoassay, 38:187-191 future, 38:194-195 high-performance liquid chromatography, 38:158-159 history, 38:150-15 1 immunofluorescence, 38:186-187 immunoglobulin-binding proteins, 38~157-158 immunotherapy, 38:180 cancer, 38:181-182 immunoglobulin fragments, 38:180-181 immunotoxins, 38:182-183, 185 Pseudomonas exotoxin, 38:184-185 ricin, 38:183-184 monoclonal antibodies, 38161-162 bispecificity, 38166-167 catalytic antibodies, 38167-170 fusion, 38:162 12 CUMULATIVE SUBJECT INDEX Antibody technologies (continued) hybridomas, 38163-164 nonmurine, 38164-165 specificity, 38:165-166 polyclonal antibodies adjuvants , 3 8153-1 55 delivery, 38:155 idiotypes, 38:155-157 lipid-derivatized antibodies, 38:155 synthetic peptides, 38:151-153 precipitation, 38:158 radiolabels, 38:186 recombinant antibodies eukaryotes, 38:171-172 heterochimeras, 38:174-175 homochimeras, 38:175-177 libraries, 38:172-174 mutagenesis, 38:174 prokaryotes, 38170-1 71 single chain, 38:177-179 size, 38:179-180 recombinant DNA affinity purification, 38:192 epitope mapping, 38:192-194 immunoscreening, 38:191-192 transplactation, 38181 Antiflammatory activity, Gonoderrno, 37:119-120 Antifoams adverse effects of, 33:189-191 carriers, 33:185, 189 characteristics, desired, 33:187-188 chemical, for fermentations, 33:181-184 combined with other defoaming methods, 33:211-213 definition of, 33:180 foam breakage mechanisms of, 33:185-186 oxygen transfer rate and, 33:191-192 selection criteria, 33:186-189 type and nature of, 33:180-185 Antifungal agents, from streptomycetes, tolerance to, in producer organisms, 25:152 Antigens antibody technologies and, 38:150, 187, 192,194 enzyme immunoassay, 38:187-189, 191 immunotherapy, 38:180-182 monoclonal antibodies, 38:162, 164-167,169-170 polyclonal antibodies, 38:151-156 recent developments, 38:160 recombinant antibodies, 38:174-177, 17S180 bacterial gene transfer in soil and, 35:151 biotechnological processes and, 36:77 biotechnology and, 34:290, 292, 294, 295 foodborne yeasts and, 36:180 Ganoderma, 37:118 levan and, 35:180, 190 microbial cytochromes P450 and, 36:163 protein analysis and, 36:291, 316, 323 recombinant E.

Coli K-12 and, m 1 0 5 , 112 CUMULATIVE SUBJECT INDEX pBR322, 36239,91,97 water, 36:97,102-103 Amylase from bacteria, 41203 pectin extraction, 39233 solid-state fermentation and, 38:103 a-Amylase bacterial acidic, sources, 24260 alkaline, sources, 24:258-259 biosynthetic aspects culture selection, 24:273-275 genetic aspects, 24271-273 induction and catabolite repression, 24:267-271 relation to growth cycle, 24:260-263 relation to RNA metabolism, 24:264-265 uses, 24257 thermophilic types, sources, 24258-259 production by solid-state fermentation and, 35~1-3,46,47 advantages, 35%-13 aeration, 35:33, 34 autoclaving, 35:31 bacterial cultures, 35:19-21 bacterial strains, 35:7, 8 clarification, 35:39, 40 culture vessels, 35:30, 31 economic considerations, 35:42, 43 enzyme characteristics, 35:40-42 recovery, 35:36-39 yields, 35:35, 36 growth, 35:34, 35 history, 35:18, 19 incubation, 35:32, 33 industrial production, 35:13-18 inoculum, 35:31,32 modes for economy, 35:3-7 moisture, 3526-29 pH, 3529, 30 research needs, 35:43-46 solid substrates, 3523,24 supplementary nutrients, 35:25, 26 PAmylase, solid-state fermentation and, 35:4 Amyloglucosidase, see Glucan 1,4-aglucosidase 9 Amylopectin, see Amioca AMY mutants, microbial cytochromes P450 and, 36:155 Anabaena hydrogen production technology and, 38279 PAH metabolism, 30:37 Anabaena variabilis, hydrogen production technology and, 38248 Anabolic pathways, transfer by recombinant DNA technology, 27~58-61 Anaerobic aromatic metabolism, herbicides and pesticides and, 36:32-36 Anaerobic methane oxidation, in aquatic environments, 26:12-18 Anaerobiosis anoxygenic phototrophic bacteria and carbon assimilation, 38:259, 262-266 classification, 38:216 enzymes, 38:243, 255 hydrogen metabolism, 38219-220 hydrogen production, 38:220,225, 229, 268-269,276 solid-state fermentation and, 38:103, 125 Anchorage-dependent cells, hydrodynamic shear stress, 37:195-202, 218 Anchorage-independent cells, hydrodynamic shear stress, 37:202-208 Ancillary proteins, microbial cytochromes P450 and, 36:134-135 Androgens, plant cell transformation of, 25222 Anemia, from cadmium, 23:69 Angiotensin-converting enzyme, Ganoderma, 37:114,122 Anguidine, substances from fungi and, 34:229 Anhydrogalacturonic acid, determination methods, 39:228-229 Anhydrotetracycline hydratase, properties of, 28:34 Aniline, biodegradation in subsurface, 33:151 Anilinothiazolinone, protein analysis and, 36:297,301 10 CUMULATIVE SUBJECT INDEX Animals biotechnological processes and, 36~80-82 cadmium effects on, 2367-78 foodborne yeasts and, 36:184, 195 patent law and, 35284, 288-291 vanishing, gene banks from, 27:61 waste, bioconversion to methane, 3248 digestion profitability beef feedlot, 3257, 59-63 dairy cattle, 3253-59 poultry, 3254-66, 67 swine, 3264 input baseline variables, 32:39-40 process parameters, 32:49, 50 Anions exchange capacity, xenobiotics and, 35201, 216, 217, 2 2 1 exchange chromatography, antibody technologies and, 38:159 inorganic, nickel toxicity and, 29~226-228 Anisomycin, tolerance to, in producer organisms, 25:149-150 Ankistrodesm us, 3 0106 Anopheles albimanus, rearing, 42222 Anoxygenic phototrophic bacteria, 38211-213, 281 biofuel production, 41245-260 biopolyester production, 41227-239 biotechnical potential, 41227-269 carbon assimilation, 38259-267 classification, 38913-217, 219 degradation of aromatic compounds, 41:211-212 enzymes hydrogenase, 38249-259 nitrogenase, 38:240-249 hydrogen metabolism, 382 18-220 hydrogen production, 38220-221 electron donors, 38221-224 immobilization technology, 38~235-240 optimization of process, 38229-235 substrate conversion efficiency, 38~224-229 technology cocultures, 3 8 2 6 8 4 6 9 , 271 photobioreactors, 38270-279 wastewaters, 38267-268 other uses, 41215-218 pesticide production, 41234-238 regulatory proteins in, 41:69-70 SCP production, 41:180-190 soil, 41263-267 taxonomic groups, 41:174-180 use as biofertilizer, 41257, 260-269 for leguminous crops, 41267 in paddy soils, 41263-267 uses, 38279-281 for waste treatment, 41204-215 Anthocyanin, fruit juice clarification and, 39947 Anthracene, 41:72-78 bacterial oxidation, pathway, 30:47 biodegradation, in natural habitats, 30:63 fungal oxidation, pathway, 3 0 4 8 4 9 microbial metabolism, 30:38, 46-51 structure, 3032 Anthracyclines antibiotics, as drug metabolism models, 25:190-192 antitumor, production by Streptomyces species, 32208 bioconversion by blocked S.

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