Download Drug Discovery and Evaluation: Pharmacological Assays by Hans G. Vogel PDF

By Hans G. Vogel

The recent version of this winning reference bargains either state-of-the-art and vintage pharmacological tools. completely revised and multiplied to 2 volumes, it bargains an up to date number of the main usually used assays for reliably detecting the pharmacological results of capability medicines. each bankruptcy has been up-to-date, and diverse assays were additional. all the greater than 1,000 assays includes an in depth protocol outlining goal and motive, and a serious evaluation of the consequences and their pharmacological and medical relevance.

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Extra resources for Drug Discovery and Evaluation: Pharmacological Assays

Sample text

Influence on Lipoprotein- Lipase Activity . . . . . Influence on Several Steps of Cholesterol Absorption and Formation . . . . . Inhibition of Cholesterol Biosynthesis . . . . . . General Considerations on Cholesterol Biosynthesis . . Determination of HMG-CoA-Reductase Inhibitory Activity General Considerations on HMG-CoA-Reductase . . . Inhibition of the Isolated Enzyme HMG-CoA-Reductase in Vitro . . . . . . . . Inhibition of the Incorporation of 14 C-Sodium Acetate into Cholesterol in Isolated Liver Cells .

Determination of Advanced Glycation End Products (AGE) . Measurement of Reactive Oxygen Species (ROS) Production . Insulin Analogs: Assessment of Insulin Mitogenicity and IGF-I Activity . . . . . . . . . . . . Introduction and Application to Insulin Analogs . . . . Insulin Receptor Affinity . . . . . . . . . . Signaling Via Insulin Receptor . . . . . . . . . IGF-I Receptor Affinity . . . . . . . . . . . Signaling via IGF-1 Receptor . . . .

Safety Pharmacology of Drugs with Anti-obesity Activity . . . . . . . 1609 1609 1610 1612 1613 1613 1614 1614 1614 1617 1621 1622 1622 1622 . . . . . . . 1625 1625 1629 1629 1630 1633 1635 1636 1636 1639 1639 1641 1642 1643 . . . . . . . 1643 1645 1650 1650 1651 1652 1652 1652 1655 1657 1657 1658 1659 1660 Contents XLIII Chapter M Anti-Atherosclerotic Activity . . . . . . . . . . . . . 7 Induction of Experimental Atherosclerosis . . . . General Considerations .

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