By Donald M. Jerina (Eds.)
content material: Cytochrome P-450 : its function in oxygen activation for drug metabolism / R.W. Estabrook and J. Werringloer --
artificial types for the response levels of cytochrome P-450 / James P. Collman and Thomas N. Sorrell --
Biochemical stories on drug metabolism : isolation of a number of sorts of liver microsomal cytochrome P-450 / M.J. Coon, J.L. Vermilion, K.P. Vatsis, J.S. French, W.L. Dean, and D.A. Haugen --
solution of a number of kinds of rabbit liver cytochrome P-450 / Eric F. Johnson and Ursula Muller-Eberhard --
Enantiomeric selectivity and perturbation of product ratios as equipment for learning the multiplicity of microsomal enzymes / William F. Trager --
position of purified cytochrome P-448 and epoxide hydrase within the activation and cleansing of benzo[a]pyrene / W. Levin, A.W. wooden, A.Y.H. Lu, D. Ryan, S. West, A.H. Conney, D.R. Thakker, H. Yagi, and D.M. Jerina --
In vitro reactions of the diastereomeric 9,10-epoxides of (+) and ( --
)-trans-7,8-dihydroxy-7,8-dihydrobenzo-[a]pyrene with polyguanylic acid and facts for formation of an enantiomer of every diastereomeric 9,10-epoxide from benzo[a]pyrene in mouse epidermis / P.D. Moore, M. Koreeda, P.G. Wislocki, W. Levin, A.H. Conney, H. Yagi, and D.M. Jerina --
position of metabolic activation in chemical-induced tissue damage / Sidney D. Nelson, Michael R. Boyd, and Jerry R. Mitchell.
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Additional resources for Drug Metabolism Concepts
C o l l m a n , J. , Gagne, R. , and Reed, C. , J. Amer. Chem. Soc. (1974) 96, 2629. C o l l m a n , J. , Sorrell, T. , Jameson, G. , R o d l e y , G. , and Robinson, W. , u n p u b l i s h e d results. , C o l l m a n , J. , Gagne, R. , and Reed, C. , J. Chem. Phys. (1975) 63, 5375. Kuehn, C. G. , J. Amer. Chem. Soc. (1975) 98, 689. Sorrell, T. N. , and C o l l m a n , J. , unpublished data. H a l b e r t , T. R. and C o l l m a n , J. , unpublished data. , p r i v a t e communication. 3 Biochemical Studies on Drug Metabolism: Isolation of Multiple Forms of Liver Microsomal Cytochrome P-450 M.
J. Biol. Chem. 250, 2157-2163. 23. Remmer, H. , Annals o f the New York Acad. Sci. (1965) 123, 79-97. 24. , Pharmacol. Rev. (1967) 19, 317-366. 25. L. , T h i s volume. 26. , Science (1955) 121, 603. 27. R. , J. Pharmacol. exp. Ther. (1955) 114, 409-417. 28. , J. Biol. Chem. (1957) 228, 753-766. 29. , Cancer Res. (1958) 18, 469-477. 30. C. , J. Amer. Chem. Soc. (1957) 79, 1004-1005. 31. J. , J. Biol. Chem. (1957) 225, 103114. 32. , and Rosenthal, O. in 24 33. 34. 35. 36. ch001 37. 38. 39. 40.
T h i s work is f a r from complete so t h a t the p r e s e n t paper is a p r o g r e s s report. Many o t h e r l a b o r a t o r i e s have a l s o c o n t r i b u t e d t o m o d e l l i n g t h e s e P-450 s t a g e s , but t h e p r e s e n t a c c o u n t will not attempt t o r e v i e w the c o n t r i b u t i o n s o f o t h e r groups in any d e p t h . Consider a simplified reaction c y c l e f o r the soluble, bacterial camphor h y d r o x y l a s e , P-450 , from Pseudomonas p u t i d a (3).