By U.A. Meyer, Jean-Michel Metry, Urs B. Meyer
This important paintings comprehensively covers all problems with drug routine compliance. In 3 sections--Clinical Trials, sufferer administration, and destiny Aspects--it bargains with an issue of dialogue and curiosity.
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Additional info for Drug regimen compliance : issues in clinical trials and patient management
Only the good compliers are randomized. This pre-randomization compliance screen was used as early as 1967 in the Veteran’s Administration Cooperative Study Group on Antihypertensive Agents, and later in the Physicians’ Health Study and the SOLVD trial. The run-in phase seems to be especially indicated in long-term and intervention studies with expensive patient follow-up. There may, however, be problems with blinding, generalizability and the evaluation of the safety profile. For more details see Probstfield’s review15.
Insull W Jr. Workshop summary. Controlled Clin Trials 5: 451–8, 1984. 14. Kass MA, Gordon M, Meltzer DW. Can ophthalmologists correctly identify patients defaulting from pilocarpine therapy? Am J Ophthalmol 101: 524–30, 1986. 15. Cramer JA, Scheyer RD, Mattson RH. Compliance declines between clinic visits. Arch Intern Med 150: 1509–10, 1990. SEQ 0020 JOB WIL8222-001-001 PAGE-0020 CHAP 1 1-22 REVISED 10DEC98 AT 08:20 BY TF DEPTH: 58 PICAS WIDTH 40 PICAS 20 DRUG REGIMEN COMPLIANCE 16. Feinstein AR.
However carefully they were controlled statistically and scientifically, Drug Regimen Compliance: Issues in Clinical Trials and Patient Management. -M. A. Meyer. 1999 John Wiley & Sons Ltd. ’ Poor compliance may have been negligible or even beneficial for centuries, as long as almost no pharmacologically effective therapies were available. However, since the early days of the use of antibiotics, such as streptomycin, isoniazid, and penicillin, compliance has become an important issue of effective patient care4.