Download Endocrine Disruptors Part II (Handbook of Environmental by M. Metzler PDF

By M. Metzler

The sector of endocrine disruption or endocrine lively compounds (EACs), that is simply rising and nonetheless debatable, is comprehensively lined via top specialists in quantity three, Subvolumes L (Part I) and M (the current quantity, half II). the key sessions of endocrine energetic chemical substances are mentioned, in addition to equipment for his or her detection and their organization with health and wellbeing disturbances in people and flora and fauna. The etiology of a number of of the human ailments linked to endocrine disruptors, e.g. breast and prostate melanoma, diminished fertility and malformations, remains to be poorly understood, and the present kingdom of information is gifted. because hormonally energetic brokers seem to have the opportunity of either adversarial and invaluable results, the proof of overall healthiness merits linked to endocrine energetic compounds in people is additionally offered. easy chapters at the mode of motion of EACs and at the etiology of the linked ailments facilitate the certainty of this complicated topic for non-medical readers.

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Sample text

However, Whittemore et al. [22] estimated that dietary fat intake may account for only 10–15% of the difference in prostate cancer occurrence between European Americans and African Americans or Asians. A mechanism of an enhancing effect of fat on prostate carcinogenesis is not understood, but several hypotheses, including hormonal mediation, have been discussed elsewhere [13, 17, 57, 60]. In addition, a high intake of protein and energy and a low intake of dietary fiber and complex carbohydrates have been found associated with increased risk for prostate cancer in some studies [10, 13, 17, 56].

Bosland separate effects of any individual dietary factor [61]. This notion is consistent with the observed lack of any effect of dietary fat as a single factor on the induction of prostate cancer in animal models whereas epidemiological studies consistently show a positive association between prostate cancer risk and dietary fat intake (see [13, 17, 61]). Most studies of effects of dietary changes and the consumption of vegetarian or health food diets on hormonal status ([62–66], summarized in [13]) have not separately addressed effects of dietary fat.

Whether this is associated with dietary or other life-style factors or exposures to environmental pollutants is not clear. There are, to the knowledge of the author, no epidemiologic studies that explored a possible role of environmental chemicals with hormonal activity in the etiology of prostate cancer. It is noteworthy that the above summarized endocrine differences between very high risk African Americans and high risk European American were not consistent in younger and older men, and they were not similar to the differences observed between the high risk US populations and the low risk African black men [62–64, 139].

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